The NSAIDs that pose the biggest risk include: Ibuprofen: Research has found that ibuprofen, such as Advil and Motrin, can worsen existing high blood pressure (hypertension) or lead to the development of high blood pressure. These drugs also are linked to kidney damage (nephrotoxicity), worsening of heart failure, and even heart attack or stroke. A dosing card comes with the gel so you can measure the correct amount. Diclofenac epolamine 1.3% patch (Flector). Apply one patch to your most painful joint twice per day. Diclofenac sodium 1.5% liquid (Pennsaid). When used for osteoarthritis knee pain, apply 40 drops per knee, 4 times a day. Dispense in 10-drop portions to prevent spilling Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and aspirin, are a class of drugs that are commonly used to relieve pain and inflammation and reduce fever . When taken orally as a pill or tablet, NSAIDs produce systemic (whole body) effects. As such, it's natural to wonder whether NSAIDs target your thyroid gland along with all NSAIDs have different properties. Tylenol, for example, can help with a headache and fever but not the inflammation that Advil can address. Naproxen is the strongest of the OTC NSAIDs, which include: Advil, Motrin (ibuprofen) Aleve, Naprosyn (naproxen) Bayer, Ecotrin, Bufferin (aspirin) Tylenol ( acetaminophen) If you are allergic to diclofenac sodium, aspirin, ibuprofen or any other NSAID, or to any of the other ingredients of this medicine (listed in section 6). Signs of a hypersensitivity reaction include swelling of the face and mouth (angioedema), breathing problems, chest pain, runny nose, skin rash or any other allergic type reaction. Diclofenac Sodium Topical Gel, 1% may take up to 7 days to work for your arthritis pain; it is not for immediate relief. With 4 times-a-day use, you may start to feel relief within a few days. You should feel significant pain relief within 7 days of continuous use. If no pain relief in 7 days, stop use. One tablet (diclofenac 50 mg-misoprostol 200 mcg) orally 3 times a day. Maximum doses: diclofenac 150 mg/day; misoprostol 200 mcg/dose and 800 mcg/day. Comments: Monitor response to initial therapy and adjust dose and frequency to fit individual needs; consider titration of individual components if appropriate. What our experts say. There is no scientific evidence demonstrating that taking medically-advised diclofenac after receiving the COVID-19 vaccine can cause complications. Following vaccination it is common for someone to experience mild and temporary side effects such as fever, headaches etc. This is a normal response to vaccination. Speak to your doctor before taking Difene if you: • think you may be allergic to diclofenac sodium, aspirin, ibuprofen or any other NSAID, or to any of the other ingredients of Difene. (These are listed at the end of the leaflet.) Signs of a hypersensitivity reaction include swelling of the face and mouth (angioedema), breathing Diclofenac can increase your risk of fatal heart attack or stroke. Do not use Arthrotec just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Diclofenac may also cause stomach or intestinal bleeding, which can be fatal. Before taking this medicine. Diclofenac can increase your risk of fatal heart attack or stroke Cl2Xxc.